Statins as Potential Farnesoid X Receptor Modulators in Atrial Cardiomyocytes: A Gender, Age and miR328 Controlled Response
... Farnesoid X receptor (FXR) plays an important role in lipid and glucose metabolism and statins are known negative regulators of FXR expression. The role of FXR in atrial fibrillation (AF) has not been defined. MicroRNA-328 (miR-328) a small non-coding RNA contributes to adverse electrical remodeling in AF a common complication after coronary artery bypass grafting (CABG). The present study aimed to examine the levels of FXR mRNA and miR328 in 30 consecutive patients undergoing CABG.
Post reperfusion, mean (S.E.) FXR mRNA levels increased
...FXR mRNA post-pre CABG in patients under statin therapy were -2.6 units lower (95% C.I.-4.43,-0.80) than in patients not taking statins (p=0.007).
Each additional year of age results in FXR mRNA being 0.27 units higher (95% C.I. 0.04, 0.48) (p=0.018). Female patient FXR mRNA was 2.10 units higher (95% C.I. 0.12, 4,09) than their male counterparts
... These results suggest that FXR regulation during CABG is dependent on statin therapy, is gender specific and increases with age. Also the inverse relation of FXR mRNA with miR-328 suggests a possible interplay between metabolic and electrical substrate alterations for the atrial myocardium during CABG.