APOB48 ja APOB-100 apolipoproteiinit

 

 https://www.genecards.org/cgi-bin/carddisp.pl?gene=APOB&keywords=Apolipoprotein,B

ApoB-48  tutkimuksista: ApoB-48 syntetisoituu suolessa.  ApoB-100 syntetisoituu  maksassa. 

 https://pubmed.ncbi.nlm.nih.gov/40591354/

MTTP geeni, https://www.genecards.org/cgi-bin/carddisp.pl?gene=MTTP&keywords=MTTP

MTTP (Microsomal Triglyceride Transfer Protein) is a Protein Coding gene. Diseases associated with MTTP include Abetalipoproteinemia and Abdominal Obesity-Metabolic Syndrome 1. Among its related pathways are Plasma lipoprotein assembly, remodeling, and clearance and Cholesterol metabolism. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and lipid transporter activity.  

MTP proteiini mikrosomaalinen triglyserejä erittävä proteiini  (  vaikuttaa suolistossa  ApoB48 ja  maksassa ApoB100 lipoproteiinieneritystä. 

 The microsomal triglyceride transfer protein (MTP) is essential for the secretion of apolipoprotein B (apoB)48- and apoB100-containing lipoproteins in the intestine and liver, respectively. Loss of function mutations in MTP cause abetalipoproteinemia.

 https://pubmed.ncbi.nlm.nih.gov/35931202/

KELCH-12 proteiinin osuus  poissuljettu DOI: 10.1152/ajpendo.00219.2025   KLHL12 has been reported to regulate the trafficking of large COPII vesicles from the ER to the Golgi, including VLDL secretion in the hepatoma cells. Lipid absorption in the intestine involves COPII-mediated trafficking of chylomicron in enterocytes. Our findings demonstrate that the deletion of intestinal Klhl12 does not significantly alter systemic lipid levels or body weight under different dietary challenges, suggesting that KLHL12 is not required for lipid absorption and chylomicron metabolism

https://pubmed.ncbi.nlm.nih.gov/40514653/ 

https://pubmed.ncbi.nlm.nih.gov/40514653/ 

AI

Further Research and Clinical Implications:

• Mechanisms:

  While the link between ApoB and cancer is becoming clearer, the exact mechanisms by which ApoB influences tumor growth, metastasis, and response to therapy are still being investigated. 

  Clinical Applications:

 

Further research is needed to validate ApoB as a reliable prognostic marker and to explore its potential as a therapeutic target in various cancers. 

Individualized Treatment: Understanding the role of ApoB in cancer may lead to more personalized treatment strategies, tailoring therapies based on individual ApoB levels and other relevant factors